{
  "source": "https://pubmed.ncbi.nlm.nih.gov/",
  "retrieved_at": "2026-08-29",
  "method": "PubMed ESearch query counts and the same query AND humans[MeSH]. The Humans MeSH filter is not a count of clinical trials and can omit unindexed human research. Broad molecule queries do not establish evidence for a specific cosmetic or therapeutic use.",
  "rows": [
    {
      "entity": "bpc-157",
      "query": "BPC-157 OR \"BPC 157\"",
      "query_total": 227,
      "humans_mesh_count": 53,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28BPC-157%20OR%20%22BPC%20157%22%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28BPC-157%20OR%20%22BPC%20157%22%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "cjc-1295",
      "query": "\"CJC-1295\"",
      "query_total": 33,
      "humans_mesh_count": 21,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22CJC-1295%22%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22CJC-1295%22%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "collagen-skin",
      "query": "\"collagen supplementation\" skin",
      "query_total": 26,
      "humans_mesh_count": 13,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22collagen%20supplementation%22%20skin%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22collagen%20supplementation%22%20skin%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "exosomes-skin",
      "query": "exosome skin",
      "query_total": 1662,
      "humans_mesh_count": 1012,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28exosome%20skin%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28exosome%20skin%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "ghk-cu",
      "query": "\"GHK-Cu\" OR \"GHK copper\"",
      "query_total": 122,
      "humans_mesh_count": 51,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22GHK-Cu%22%20OR%20%22GHK%20copper%22%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22GHK-Cu%22%20OR%20%22GHK%20copper%22%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "ipamorelin",
      "query": "ipamorelin",
      "query_total": 54,
      "humans_mesh_count": 28,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28ipamorelin%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28ipamorelin%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "metformin-aging",
      "query": "metformin aging",
      "query_total": 1612,
      "humans_mesh_count": 1004,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28metformin%20aging%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28metformin%20aging%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "nicotinamide-riboside",
      "query": "\"nicotinamide riboside\"",
      "query_total": 950,
      "humans_mesh_count": 419,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22nicotinamide%20riboside%22%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22nicotinamide%20riboside%22%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "nmn",
      "query": "\"nicotinamide mononucleotide\"",
      "query_total": 1711,
      "humans_mesh_count": 592,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22nicotinamide%20mononucleotide%22%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22nicotinamide%20mononucleotide%22%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "pdrn",
      "query": "polydeoxyribonucleotide OR PDRN",
      "query_total": 4394,
      "humans_mesh_count": 1055,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28polydeoxyribonucleotide%20OR%20PDRN%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28polydeoxyribonucleotide%20OR%20PDRN%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "pdrn-skin",
      "query": "(polydeoxyribonucleotide OR PDRN) AND skin",
      "query_total": 128,
      "humans_mesh_count": 71,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%28polydeoxyribonucleotide%20OR%20PDRN%29%20AND%20skin%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%28polydeoxyribonucleotide%20OR%20PDRN%29%20AND%20skin%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "prp-knee",
      "query": "\"platelet-rich plasma\" knee",
      "query_total": 1797,
      "humans_mesh_count": 1044,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22platelet-rich%20plasma%22%20knee%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22platelet-rich%20plasma%22%20knee%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "rapamycin-aging",
      "query": "rapamycin aging",
      "query_total": 3492,
      "humans_mesh_count": 1785,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28rapamycin%20aging%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28rapamycin%20aging%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "resveratrol",
      "query": "resveratrol",
      "query_total": 21601,
      "humans_mesh_count": 9689,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28resveratrol%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28resveratrol%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "spermidine",
      "query": "spermidine longevity",
      "query_total": 164,
      "humans_mesh_count": 80,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28spermidine%20longevity%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28spermidine%20longevity%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "taurine-aging",
      "query": "taurine aging",
      "query_total": 672,
      "humans_mesh_count": 217,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28taurine%20aging%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28taurine%20aging%29%20AND%20humans%5BMeSH%5D"
    },
    {
      "entity": "tb-500",
      "query": "\"TB-500\" OR thymosin beta-4",
      "query_total": 1074,
      "humans_mesh_count": 605,
      "retrieved_at": "2026-08-29",
      "query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22TB-500%22%20OR%20thymosin%20beta-4%29",
      "humans_query_url": "https://pubmed.ncbi.nlm.nih.gov/?term=%28%22TB-500%22%20OR%20thymosin%20beta-4%29%20AND%20humans%5BMeSH%5D"
    }
  ]
}