Reported pain relief from stem cell infusions appears to peak around 3–4 months, with gradual attenuation thereafter. Some patients describe sustained benefit at 9–12 months; others note decline by month 6. No standardised outcome assessments across trials permit precise duration statements. Repeat infusions are proposed by some clinics but lack safety data on cumulative dosing. Long-term durability remains unknown.
Complex Regional Pain Syndrome emerges following injury, surgery, or sometimes without clear precipitant, characterised by disproportionate pain, autonomic dysfunction, motor impairment, and inflammatory skin changes confined to a limb. Current management relies on physiotherapy, pain medications, and neuromodulation, yet many patients experience chronic refractory symptoms and functional disability. Stem cell research into CRPS explores whether placental mesenchymal stem cells or neurogenic derivatives might dampen persistent inflammatory signalling and promote peripheral nerve plasticity. These approaches remain at an early clinical stage, with no established cell therapy standard of care.
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Medically reviewed by StemCellAtlas’s editorial team with Kiian Nadiia, MD, PhD (Paediatric Neurologist · Medical Director, CSM Clinic Network · 12+ yrs in Autism Spectrum Disorders) of partner clinic Stem Plus (Sofia), against ISSCR, FDA & EMA guidance. Educational information, not medical advice; figures indicative.
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