Immediate post-infusion effects are negligible; patients resume normal activity within 24–48 hours. Systemic symptoms (mild fever, transient malaise) resolve within 1 week in <10% of recipients. Functional gains emerge over weeks; objective improvement in exercise capacity or cognitive clarity typically appears at 4–8 weeks. Patients should maintain baseline symptom diaries to assess change trajectory; recovery is gradual and non-linear.
Published phase I safety data and small phase II trials (n=20–80 per arm) document symptomatic improvement in fatigue severity, exercise tolerance, and cognitive clarity in 40–55% of infused participants over 8–12 weeks. Objective markers—circulating microclot burden, endothelial dysfunction indices, IL-6 levels—show modest reduction in responder subgroups. One multicentre registry reports durable functional improvement (60-metre walk distance, sustained exertion capacity) persisting at 6 months in 45% of treated cohorts. Blinded controlled efficacy trials remain pending.
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Medically reviewed by StemCellAtlas’s editorial team with Dr Polina Krasenova (Haematologist · Clinical Haematology & Integrative Oncology · 15+ yrs cell therapy) of partner clinic Stem Plus (Sofia), against ISSCR, FDA & EMA guidance. Educational information, not medical advice; figures indicative.
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