Chronic Kidney Disease: cell-therapy evidence by therapy class
Across every stem-cell intervention, ClinicalTrials.gov holds 88 registered records for Chronic Kidney Disease — 9 recruiting, 10 at Phase 3 or 4, in 28 countries. Snapshot 2026-08-29.
The condition, and why cells are proposed
Chronic kidney disease is progressive nephron loss with fibrosis and inflammation. Cell approaches aim to slow decline rather than regenerate nephrons, and the kidney's limited regenerative capacity makes restoration claims implausible. Registered work sits close to nephrology practice, which means endpoints are unusually well defined compared with softer indications.
Therapy classes side by side
Counts come from separate registry queries per class; a study testing two interventions can appear in more than one row, so rows do not sum to the all-interventions total.
Geography of the research
United States accounts for about 64% of country mentions among sampled studies; 28 countries host at least one site.
| Country | Studies with a site there |
|---|---|
| United States | 54 |
| Italy | 7 |
| China | 6 |
| Germany | 4 |
| Spain | 3 |
| South Korea | 3 |
| Brazil | 2 |
| India | 2 |
The largest registered studies
Sorted by planned enrolment — size is not quality, but a 300-participant trial can answer questions a 12-participant series cannot.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT03899298 — Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions | Phase 1 | Not Yet Recruiting | 5,000 | R3 Stem Cell | 2019-09-01 |
| NCT02639936 — New Generation IGRA in Immunocompromised Individuals | n/a | Completed | 2,663 | Tuberculosis Network European Trialsgroup | 2015-12 |
| NCT00949052 — Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for Cancer | n/a | Terminated | 1,000 | Vanderbilt-Ingram Cancer Center | 2009-01 |
| NCT00003883 — Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation | Phase 3 | Completed | 578 | Fred Hutchinson Cancer Center | 1998-10 |
| NCT00957736 — Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant | n/a | Terminated | 252 | Vanderbilt-Ingram Cancer Center | 2008-11 |
| NCT01305200 — Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant | Phase 3 | Completed | 226 | Children's Oncology Group | 2011-03 |
Most recently registered
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT07592000 — Breakthrough - T1DM and Chronic Kidney Disease | n/a | Recruiting | n/a | University of Chicago | 2027-04-29 |
| NCT07358195 — Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation | n/a | Not Yet Recruiting | n/a | Massachusetts General Hospital | 2026-07 |
| NCT07572890 — Adia Med of Winter Park LLC Chronic Kidney Disease Research Study | n/a | Recruiting | n/a | Adia Med of Winter Park LLC | 2026-05-18 |
| NCT07275788 — A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD) | n/a | Recruiting | n/a | Regend Therapeutics | 2026-01-08 |
| NCT07240987 — Mesenchymal Stem Cells for Chronic Kidney Diseases | n/a | Not Yet Recruiting | n/a | The First Affiliated Hospital of Air Force Medicial Universi | 2026-01-01 |
Reading this honestly
None of these numbers say the therapy works. They say how much organised research exists and how far along it is; effect sizes live in published results, not registry entries. For Chronic Kidney Disease specifically, the practical question is which registered study — if any — matches the product a provider is offering, and what its outcome measures actually are.
Frequently asked
How many stem-cell trials exist for Chronic Kidney Disease?
88 registered records mention a stem-cell intervention for this condition (2026-08-29 snapshot), of which 9 were recruiting.
Which therapy class is furthest along for Chronic Kidney Disease?
Ranked by Phase 3/4 records: HSCT (4), MSC (1), exosomes (0), PRP (0).
Does a recruiting trial mean I can be treated?
No. Trials have eligibility criteria, and joining one is not the same as buying a treatment. Paying a clinic for an unproven intervention outside a registered study gives you neither the protections nor the data collection of a trial.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
Download the query data
Query totals are full API matches; status, phase and country counts describe the first up to 400 returned records per query. Query classes overlap and must not be summed as unique trials. Counts are not treatment outcomes. Snapshot: 2026-08-29. Methods and field definitions.