Osteoporosis & Bone Health: cell-therapy evidence by therapy class
Across every stem-cell intervention, ClinicalTrials.gov holds 14 registered records for Osteoporosis & Bone Health — 2 recruiting, 0 at Phase 3 or 4, in 10 countries. Snapshot 2026-08-29.
The condition, and why cells are proposed
Osteoporosis is loss of bone mineral density and microarchitecture, and it already has drugs with fracture-reduction evidence. Cell approaches target osteoblast function or marrow niche support, so any new entrant has to be judged against established therapy rather than against nothing.
Therapy classes side by side
| Therapy class | Registered | Recruiting | Phase 3/4 | Countries |
|---|---|---|---|---|
| MSC | 7 | 0 | 0 | 6 |
| HSCT | 3 | 0 | 0 | 1 |
| exosomes | 0 | 0 | 0 | 0 |
| PRP | 0 | 0 | 0 | 0 |
Counts come from separate registry queries per class; a study testing two interventions can appear in more than one row, so rows do not sum to the all-interventions total.
Geography of the research
United States accounts for about 36% of country mentions among sampled studies; 10 countries host at least one site.
| Country | Studies with a site there |
|---|---|
| United States | 5 |
| Antigua and Barbuda | 1 |
| Switzerland | 1 |
| Spain | 1 |
| China | 1 |
| United Kingdom | 1 |
| Belgium | 1 |
| Denmark | 1 |
The largest registered studies
Sorted by planned enrolment — size is not quality, but a 300-participant trial can answer questions a 12-participant series cannot.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06065852 — National Registry of Rare Kidney Diseases | n/a | Recruiting | 35,000 | UK Kidney Association | 2009-11-06 |
| NCT02985424 — Polymyalgia Rheumatica and Giant Cell Arteritis | n/a | Unknown | 80 | Svendborg Hospital | 2017-05 |
| NCT00321932 — Zoledronic Acid in Preventing Osteoporosis in Patients Undergoing Donor Stem Cell Transplant | Phase 2 | Completed | 61 | University of Minnesota | 2005-07 |
| NCT03197623 — Safety and Tolerability of Intravenous LLP2A-Alendronate for Osteopenia Secondary to Glucocorticoids | Phase 1 | Completed | 58 | Nancy E. Lane, MD | 2016-10-14 |
| NCT01656629 — Stem Cell Recruitment in Osteoporosis Therapy | n/a | Terminated | 55 | Johns Hopkins University | 2012-08 |
| NCT04488432 — Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell Transplant | n/a | Completed | 45 | University Hospital, Brest | 2019-11-27 |
Most recently registered
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06949137 — Intravenous Infusion of Human Mesenchymal Stem Cells (HMM910 ) in Postmenopausal Women With Osteoporosis at High Risk of Fracture | n/a | Active Not Recruiting | n/a | HELP Therapeutics Co., Ltd. | 2025-06-20 |
| NCT05284604 — Mesenchymal Stem Cells for Age-Related Frailty | n/a | Withdrawn | n/a | VA Office of Research and Development | 2023-01-31 |
| NCT05152381 — Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Osteoporosis | n/a | Withdrawn | n/a | The Foundation for Orthopaedics and Regenerative Medicine | 2022-12-08 |
| NCT05246813 — Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP) | n/a | Recruiting | n/a | Imelda Hospital, Bonheiden | 2022-02-11 |
| NCT04501354 — Evaluation of Clinical and Bone Density Improvement After Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord on Osteoporosis Patients | n/a | Unknown | n/a | Ahmad Jabir Rahyussalim | 2020-08 |
Reading this honestly
These figures describe effort, not outcome. Published results, with their control arms and endpoints, are where benefit is decided. For Osteoporosis & Bone Health specifically, the practical question is which registered study — if any — matches the product a provider is offering, and what its outcome measures actually are.
Frequently asked
How many stem-cell trials exist for Osteoporosis & Bone Health?
14 registered records mention a stem-cell intervention for this condition (2026-08-29 snapshot), of which 2 were recruiting.
Which therapy class is furthest along for Osteoporosis & Bone Health?
Ranked by Phase 3/4 records: MSC (0), HSCT (0), exosomes (0), PRP (0).
Does a recruiting trial mean I can be treated?
No. Trials have eligibility criteria, and joining one is not the same as buying a treatment. Paying a clinic for an unproven intervention outside a registered study gives you neither the protections nor the data collection of a trial.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
Download the query data
Query totals are full API matches; status, phase and country counts describe the first up to 400 returned records per query. Query classes overlap and must not be summed as unique trials. Counts are not treatment outcomes. Snapshot: 2026-08-29. Methods and field definitions.