How many stem-cell trials for Primary Immunodeficiency are recruiting right now?
As of 2026-08-29: 13 open studies against 93 registrations overall, or 14% of the historical total.
Who these studies will actually take
Entry depends on genetic diagnosis, disease severity and donor availability, managed through specialist immunology and transplant services. Patients reach these studies by referral, not by registry browsing.
The studies currently enrolling
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06839456 — Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT | Phase 1, Phase 2 | Recruiting | 100 | Children's Hospital of Philadelphia | 2025-03-21 |
| NCT01306019 — Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID) | Phase 1, Phase 2 | Recruiting | 40 | National Institute of Allergy and Infectious Diseases (NIAID | 2012-09-25 |
| NCT06954441 — V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency | Phase 3 | Recruiting | 50 | On Pharma Importadora, Exportadora e Distribuidora de Medica | 2025-08-15 |
| NCT05071222 — Safety and Efficacy Study of Transplantation of Autologous CD34+ Cells Transduced With the G2ARTE Lentiviral Vector Expressing the DCLRE1C cDNA in Art | Phase 1, Phase 2 | Recruiting | 7 | Assistance Publique - Hôpitaux de Paris | 2023-07-19 |
| NCT04691622 — Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts | Phase 1 | Recruiting | 48 | Children's National Research Institute | 2022-03-17 |
| NCT04528355 — Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC | n/a | Recruiting | 50 | Paul Szabolcs | 2020-08-20 |
| NCT03538899 — Autologous Gene Therapy for Artemis-Deficient SCID | Phase 1, Phase 2 | Recruiting | 24 | University of California, San Francisco | 2018-05-31 |
| NCT01962415 — Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT | Phase 2 | Recruiting | 100 | Paul Szabolcs | 2014-02-04 |
What recruiting does and does not mean
A recruiting flag says a protocol cleared ethics review and enrolment is open. It says nothing about earlier results, nothing about your eligibility and nothing about price, because trials are not a purchase channel. Stale flags are common, so contact the listed coordinator rather than trusting the status field.
Sites sit in 16 countries, led by United States. Travelling for a trial rarely works unless the site has confirmed in writing that it can enrol non-residents and fund the follow-up schedule.
Who is running the studies here
Lead sponsors appearing most often for this condition. Useful for one specific check: whether the entity quoting research at you appears anywhere in it.
- National Institute of Allergy and Infectious Diseases (NIAID) — 8 registered records
- Fred Hutchinson Cancer Center — 6 registered records
- National Cancer Institute (NCI) — 5 registered records
- Paul Szabolcs — 4 registered records
- Fondazione Telethon — 3 registered records
- Genethon — 3 registered records
Frequently asked
How many stem-cell trials for Primary Immunodeficiency are recruiting right now?
13 of 93 registered records (2026-08-29).
Can I join one of these trials?
Eligibility is decided by the protocol, not by willingness to pay. Read the inclusion and exclusion list on the registry record, then contact the coordinator named there.
Do trials charge participants?
Trial participation is normally free of charge for the intervention under study; some studies even reimburse travel. Payment demands invert that relationship and should stop the conversation.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.