How many stem-cell trials for Scleroderma (Systemic Sclerosis) are recruiting right now?
As of 2026-08-29: 6 open studies against 44 registrations overall, or 14% of the historical total.
Who these studies will actually take
Transplant trials require diffuse cutaneous disease with organ involvement, defined progression velocity and cardiopulmonary fitness for conditioning. Screening is rigorous because the procedure itself carries mortality risk.
The studies currently enrolling
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT03211793 — Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis | Phase 1, Phase 2 | Recruiting | 20 | UMC Utrecht | 2021-10-06 |
| NCT05016804 — Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell IV Infusion for Systemic Sclerosis | Phase 1 | Recruiting | 20 | The Foundation for Orthopaedics and Regenerative Medicine | 2022-07-04 |
| NCT06619561 — A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD) | Phase 2 | Recruiting | 48 | Deciphera Pharmaceuticals, LLC | 2024-11-21 |
| NCT03630211 — Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis | Phase 2 | Recruiting | 8 | Paul Szabolcs | 2018-07-31 |
| NCT05029336 — Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases | Phase 2 | Recruiting | 20 | Stephan Grupp MD PhD | 2026-03 |
| NCT04356755 — Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma. | Phase 2 | Recruiting | 32 | University Hospital, Toulouse | 2020-09-22 |
What recruiting does and does not mean
The status field tracks paperwork, not promise. What matters underneath it is the eligibility list, the outcome measures the sponsor committed to, and whether a site near you is actually enrolling, all of which sit on the registry record itself.
Sites sit in 16 countries, led by United States. Travelling for a trial rarely works unless the site has confirmed in writing that it can enrol non-residents and fund the follow-up schedule.
Who is running the studies here
Lead sponsors appearing most often for this condition. Useful for one specific check: whether the entity quoting research at you appears anywhere in it.
- Fred Hutchinson Cancer Center — 3 registered records
- Northwestern University — 3 registered records
- Assistance Publique - Hôpitaux de Paris — 2 registered records
- European Society for Blood and Marrow Transplantation — 2 registered records
- UMC Utrecht — 2 registered records
- University Hospital, Montpellier — 2 registered records
Frequently asked
How many stem-cell trials for Scleroderma (Systemic Sclerosis) are recruiting right now?
6 of 44 registered records (2026-08-29).
Can I join one of these trials?
Possibly, if the criteria fit and a site can take you. Nobody can promise a place on your behalf, and any intermediary charging a fee to arrange one is not part of the trial.
Do trials charge participants?
Legitimate registered trials do not normally charge for the investigational intervention. Being asked for a large fee to enrol is a strong warning sign.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
More on this condition
- Scleroderma (Systemic Sclerosis): cell-therapy evidence and registered trials
- How much does stem cell therapy for Scleroderma (Systemic Sclerosis) cost? (2026)
- Scleroderma (Systemic Sclerosis) stem cell therapy — your questions answered (2026)
- Scleroderma (Systemic Sclerosis): cell-therapy evidence by therapy class
- MSC vs HSCT for Scleroderma (Systemic Sclerosis): what the registries show