For patients with advanced heart failure (ejection fraction <30–35%, NYHA class III–IV symptoms) failing optimised conventional therapy or awaiting transplantation, investigational stem-cell treatment may offer acceptable risk-benefit if trial access is available. Post-infarction remodelling prevention (treating within weeks of acute myocardial infarction) shows promise but requires early clinical recognition. For mild-to-moderate systolic dysfunction, conventional pharmacotherapy optimisation remains first-line. Decisions should weigh realistic expectations (5–10% ejection-fraction improvement rather than normalisation) against procedural risk and cost.
Heart failure reflects impaired cardiac contractility and/or relaxation, resulting from myocardial infarction, hypertension, cardiomyopathy, or valvular disease. Progressive cardiomyocyte death, fibrotic remodelling, and neuroendocrine dysregulation drive the syndrome. Placental mesenchymal stem cells and their exosomes limit adverse remodelling by secreting anti-fibrotic factors (anti-TGF-β signalling), promoting angiogenesis (VEGF, FGF), enhancing cardiomyocyte survival (paracrine anti-apoptotic signals), and modulating inflammatory infiltration (reduced macrophage pro-inflammatory activation). One hundred twenty-four registered clinical trials and twelve actively recruiting sites explore intracoronary or intravenous MSC delivery in post-infarction left-ventricular dysfunction, dilated cardiomyopathy, and advanced heart failure awaiting transplantation.
Am I a candidate? → · Heart Failure & Cardiac Repair: full overview → · Heart Failure & Cardiac Repair cost → · Cost →
Medically reviewed by StemCellAtlas’s editorial team with the Stem Plus medical team (physicians & scientists · GMP-certified Sofia laboratory · 25+ yrs international experience) of partner clinic Stem Plus (Sofia), against ISSCR, FDA & EMA guidance. Educational information, not medical advice; figures indicative.
GMP-сертифицированная регенеративная медицина в сердце ЕС — от €3 000–8 000, доля от цен США или Германии. Индивидуальные протоколы для пациентов из 50+ стран.
Бесплатная оценка врача