Aesthetic & Anti-Ageing: cell-therapy evidence by therapy class
Across every stem-cell intervention, ClinicalTrials.gov holds 10 registered records for Aesthetic & Anti-Ageing — 0 recruiting, 1 at Phase 3 or 4, in 5 countries. Snapshot 2026-08-29.
The condition, and why cells are proposed
Aesthetic and anti-ageing work is where cell therapy meets cosmetics, and where the evidence bar is lowest. Proposed mechanisms are paracrine: growth factors and vesicles that nudge fibroblasts into producing collagen. Because the endpoint is appearance, and appearance responds to lighting, hydration, weight and photography, this is the field where uncontrolled before-and-after images do the most persuading and the least proving.
Therapy classes side by side
| Therapy class | Registered | Recruiting | Phase 3/4 | Countries |
|---|---|---|---|---|
| MSC | 4 | 0 | 1 | 3 |
| HSCT | 0 | 0 | 0 | 0 |
| exosomes | 3 | 0 | 2 | 2 |
| PRP | 4 | 0 | 0 | 2 |
Counts come from separate registry queries per class; a study testing two interventions can appear in more than one row, so rows do not sum to the all-interventions total.
Geography of the research
United States accounts for about 56% of country mentions among sampled studies; 5 countries host at least one site.
| Country | Studies with a site there |
|---|---|
| United States | 5 |
| Indonesia | 1 |
| Italy | 1 |
| Iran | 1 |
| France | 1 |
The largest registered studies
Sorted by planned enrolment — size is not quality, but a 300-participant trial can answer questions a 12-participant series cannot.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT02642094 — Aging Mammary Stem Cells and Breast Cancer Prevention | Phase 2 | Terminated | 58 | LuZhe Sun | 2016-07 |
| NCT04450589 — A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Male Subjects With Hair Loss | n/a | Completed | 46 | Arbor Life Labs | 2018-04-11 |
| NCT04450602 — A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Female Subjects With Hair Loss | n/a | Completed | 46 | Arbor Life Labs | 2018-04-03 |
| NCT07466953 — Objective Evaluation of Intradermal MSC-Derived Exosome Therapy on Facial Skin Quality | Phase 3 | Not Yet Recruiting | 40 | Mert Ersan | 2026-07-10 |
| NCT05508191 — Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult Women | n/a | Completed | 30 | Shannaz Nadia Yusharyahya | 2022-08-17 |
| NCT01771679 — Safety Study of Bone Marrow Derived Stem Cells on Patients With Cutaneous Photoaging | Phase 1, Phase 2 | Unknown | 29 | Stemedica Cell Technologies, Inc. | 2015-07-01 |
Most recently registered
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT07466953 — Objective Evaluation of Intradermal MSC-Derived Exosome Therapy on Facial Skin Quality | n/a | Not Yet Recruiting | n/a | Mert Ersan | 2026-07-10 |
| NCT07010549 — Clinical and Instrumental Evaluation of the Face Biorevitalization Effect With the Medical Device Foliage Hydrofil | n/a | Completed | n/a | Phitogen Beauty Labs SRL | 2022-09-27 |
| NCT05508191 — Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult Women | n/a | Completed | n/a | Shannaz Nadia Yusharyahya | 2022-08-17 |
| NCT05813379 — Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation | n/a | Unknown | n/a | Isfahan University of Medical Sciences | 2022-02-01 |
| NCT07737639 — Evaluating Facial Skin Quality Changes Post-Lipofilling | n/a | Completed | n/a | L'Oreal | 2021-01-10 |
Reading this honestly
Treat this as a map of research activity. It tells you whether a claim has an evidence programme behind it — not whether the treatment helped anyone. For Aesthetic & Anti-Ageing specifically, the practical question is which registered study — if any — matches the product a provider is offering, and what its outcome measures actually are.
Frequently asked
How many stem-cell trials exist for Aesthetic & Anti-Ageing?
10 registered records mention a stem-cell intervention for this condition (2026-08-29 snapshot), of which 0 were recruiting.
Which therapy class is furthest along for Aesthetic & Anti-Ageing?
Ranked by Phase 3/4 records: exosomes (2), MSC (1), HSCT (0), PRP (0).
Does a recruiting trial mean I can be treated?
No. Trials have eligibility criteria, and joining one is not the same as buying a treatment. Paying a clinic for an unproven intervention outside a registered study gives you neither the protections nor the data collection of a trial.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
Download the query data
Query totals are full API matches; status, phase and country counts describe the first up to 400 returned records per query. Query classes overlap and must not be summed as unique trials. Counts are not treatment outcomes. Snapshot: 2026-08-29. Methods and field definitions.