Multiple Sclerosis: cell-therapy evidence by therapy class
Across every stem-cell intervention, ClinicalTrials.gov holds 92 registered records for Multiple Sclerosis — 13 recruiting, 3 at Phase 3 or 4, in 31 countries. Snapshot 2026-08-29.
The condition, and why cells are proposed
MS is immune-mediated demyelination with axonal loss. It holds an unusual position in this field: autologous haematopoietic transplantation has controlled evidence in aggressive relapsing disease and is offered in national health systems in several countries, while mesenchymal infusions marketed to MS patients have a much weaker base. The gap between those two is the single most important distinction in this indication.
Therapy classes side by side
Counts come from separate registry queries per class; a study testing two interventions can appear in more than one row, so rows do not sum to the all-interventions total.
Geography of the research
United States accounts for about 46% of country mentions among sampled studies; 31 countries host at least one site.
| Country | Studies with a site there |
|---|---|
| United States | 31 |
| Italy | 6 |
| United Kingdom | 6 |
| Spain | 5 |
| Sweden | 5 |
| Canada | 4 |
| Jordan | 3 |
| Trinidad and Tobago | 3 |
The largest registered studies
Sorted by planned enrolment — size is not quality, but a 300-participant trial can answer questions a 12-participant series cannot.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06065852 — National Registry of Rare Kidney Diseases | n/a | Recruiting | 35,000 | UK Kidney Association | 2009-11-06 |
| NCT01953523 — Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions | n/a | Completed | 3,000 | Elliot Lander | 2013-09-02 |
| NCT02674217 — Outpatient Hematopoietic Grafting in Multiple Sclerosis Employing Autologous Peripheral Blood Stem Cells | n/a | Unknown | 1,000 | Centro de Hematología y Medicina Interna | 2015-05 |
| NCT02795052 — Neurologic Stem Cell Treatment Study | n/a | Recruiting | 500 | MD Stem Cells | 2016-06 |
| NCT02157064 — Outcomes Data of Adipose Stem Cells to Treat Multiple Sclerosis | n/a | Unknown | 221 | StemGenex | 2014-05 |
| NCT05832515 — AHSCT With Fludarabine and Cyclophosphamide Based Conditioning Regimes in Patients With Multiple Sclerosis | Phase 1 | Recruiting | 200 | St. Petersburg State Pavlov Medical University | 2020-10-01 |
Most recently registered
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06228781 — Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis | n/a | Not Yet Recruiting | n/a | Tianjin Medical University General Hospital | 2026-12-01 |
| NCT07521384 — Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy | n/a | Enrolling By Invitation | n/a | Healing Hope International | 2026-06-01 |
| NCT07635693 — ATLG Levels in Autologous HSCT for Multiple Sclerosis | n/a | Recruiting | n/a | Ciceri Fabio | 2026-05-04 |
| NCT06841068 — Intrathecal Amniotic Fluid Stem Cells for Progressive Multiple Sclerosis | n/a | Withdrawn | n/a | Wake Forest University Health Sciences | 2026-02 |
| NCT06607900 — hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases | n/a | Not Yet Recruiting | n/a | Xuanwu Hospital, Beijing | 2025-07-01 |
Reading this honestly
Registration counts measure activity, not effect. A study appears here the moment it is registered — before any participant is enrolled, and regardless of whether results are ever posted. For Multiple Sclerosis specifically, the practical question is which registered study — if any — matches the product a provider is offering, and what its outcome measures actually are.
Frequently asked
How many stem-cell trials exist for Multiple Sclerosis?
92 registered records mention a stem-cell intervention for this condition (2026-08-29 snapshot), of which 13 were recruiting.
Which therapy class is furthest along for Multiple Sclerosis?
Ranked by Phase 3/4 records: HSCT (3), MSC (0), exosomes (0), PRP (0).
Does a recruiting trial mean I can be treated?
No. Trials have eligibility criteria, and joining one is not the same as buying a treatment. Paying a clinic for an unproven intervention outside a registered study gives you neither the protections nor the data collection of a trial.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
Download the query data
Query totals are full API matches; status, phase and country counts describe the first up to 400 returned records per query. Query classes overlap and must not be summed as unique trials. Counts are not treatment outcomes. Snapshot: 2026-08-29. Methods and field definitions.