Psoriasis: cell-therapy evidence by therapy class
Across every stem-cell intervention, ClinicalTrials.gov holds 11 registered records for Psoriasis — 0 recruiting, 1 at Phase 3 or 4, in 5 countries. Snapshot 2026-08-29.
The condition, and why cells are proposed
Psoriasis is T-cell-driven skin inflammation with a well-mapped cytokine cascade, and biologics targeting that cascade produce large, reproducible clearance rates. Cell approaches target the same immune axis less specifically, so the comparator bar here is unusually high.
Therapy classes side by side
| Therapy class | Registered | Recruiting | Phase 3/4 | Countries |
|---|---|---|---|---|
| MSC | 10 | 0 | 0 | 3 |
| HSCT | 0 | 0 | 0 | 0 |
| exosomes | 1 | 0 | 0 | 1 |
| PRP | 0 | 0 | 0 | 0 |
Counts come from separate registry queries per class; a study testing two interventions can appear in more than one row, so rows do not sum to the all-interventions total.
Geography of the research
China accounts for about 67% of country mentions among sampled studies; 5 countries host at least one site.
| Country | Studies with a site there |
|---|---|
| China | 8 |
| Canada | 1 |
| United States | 1 |
| Singapore | 1 |
| South Korea | 1 |
The largest registered studies
Sorted by planned enrolment — size is not quality, but a 300-participant trial can answer questions a 12-participant series cannot.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT02274792 — Study to Assess the Immunogenicity and Safety of Etanercept Produced Using a Modified Process in Patients With Plaque Psoriasis | Phase 4 | Completed | 132 | Amgen | 2015-01 |
| NCT03424629 — Safety and Efficacy of UC-MSCs in Patients With Plaque Psoriasis | Phase 1 | Unknown | 57 | Tianjin Ever Union Biotechnology Co., Ltd. | 2018-06-01 |
| NCT02491658 — Safety and Efficacy of UC-MSCs in Patients With Psoriasis Vulgaris | Phase 1, Phase 2 | Unknown | 30 | Affiliated Hospital to Academy of Military Medical Sciences | 2015-04 |
| NCT04785027 — Comparison of PSORI-CM01 Formula vs Gu Ben Hua Yu Formula Combined With AD-MSCs in Psoriasis | Phase 1, Phase 2 | Unknown | 16 | Guangdong Provincial Hospital of Traditional Chinese Medicin | 2021-03-17 |
| NCT03765957 — Clinical Research on Treatment of Psoriasis by Human Umbilical Cord-derived Mesenchymal Stem Cells | Early Phase 1 | Unknown | 12 | Central South University | 2019-02-20 |
| NCT05523011 — Safety and Tolerability Study of MSC Exosome Ointment | Phase 1 | Completed | 10 | Paracrine Therapeutics Dermatology Pte. Ltd. | 2022-03-08 |
Most recently registered
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT05523011 — Safety and Tolerability Study of MSC Exosome Ointment | n/a | Completed | n/a | Paracrine Therapeutics Dermatology Pte. Ltd. | 2022-03-08 |
| NCT03745417 — Efficacy and Safety of Expanded UCMSCs On Patients With Moderate to Severe Psoriasis | n/a | Unknown | n/a | Guangdong Provincial Hospital of Traditional Chinese Medicin | 2021-08-31 |
| NCT04785027 — Comparison of PSORI-CM01 Formula vs Gu Ben Hua Yu Formula Combined With AD-MSCs in Psoriasis | n/a | Unknown | n/a | Guangdong Provincial Hospital of Traditional Chinese Medicin | 2021-03-17 |
| NCT04275024 — Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis Patients | n/a | Completed | n/a | Guangdong Provincial Hospital of Traditional Chinese Medicin | 2020-04-01 |
| NCT03392311 — Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment in Patients With Moderate to Severe Psoriasis | n/a | Completed | n/a | Guangdong Provincial Hospital of Traditional Chinese Medicin | 2019-07-23 |
Reading this honestly
A registry is a plan repository. Counting entries tells you what people intended to study, which is a weaker thing than what they found. For Psoriasis specifically, the practical question is which registered study — if any — matches the product a provider is offering, and what its outcome measures actually are.
Frequently asked
How many stem-cell trials exist for Psoriasis?
11 registered records mention a stem-cell intervention for this condition (2026-08-29 snapshot), of which 0 were recruiting.
Which therapy class is furthest along for Psoriasis?
Ranked by Phase 3/4 records: MSC (0), HSCT (0), exosomes (0), PRP (0).
Does a recruiting trial mean I can be treated?
No. Trials have eligibility criteria, and joining one is not the same as buying a treatment. Paying a clinic for an unproven intervention outside a registered study gives you neither the protections nor the data collection of a trial.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
Download the query data
Query totals are full API matches; status, phase and country counts describe the first up to 400 returned records per query. Query classes overlap and must not be summed as unique trials. Counts are not treatment outcomes. Snapshot: 2026-08-29. Methods and field definitions.