Diabetes (Type 1 & 2): cell-therapy evidence by therapy class
Across every stem-cell intervention, ClinicalTrials.gov holds 65 registered records for Diabetes (Type 1 & 2) — 4 recruiting, 5 at Phase 3 or 4, in 23 countries. Snapshot 2026-08-29.
The condition, and why cells are proposed
The registry entries here are dominated by type 1 diabetes, an autoimmune destruction of beta cells. Two distinct strategies appear: immune reset around new-onset disease, and beta-cell replacement from stem-cell-derived islets. The second is the most genuinely transformative line of work in the whole field, and it is also the one most often invoked by clinics offering something entirely different.
Therapy classes side by side
Counts come from separate registry queries per class; a study testing two interventions can appear in more than one row, so rows do not sum to the all-interventions total.
Geography of the research
United States accounts for about 30% of country mentions among sampled studies; 23 countries host at least one site.
| Country | Studies with a site there |
|---|---|
| United States | 17 |
| China | 17 |
| Brazil | 4 |
| Canada | 4 |
| United Kingdom | 3 |
| Sweden | 3 |
| Egypt | 2 |
| Jordan | 2 |
The largest registered studies
Sorted by planned enrolment — size is not quality, but a 300-participant trial can answer questions a 12-participant series cannot.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06065852 — National Registry of Rare Kidney Diseases | n/a | Recruiting | 35,000 | UK Kidney Association | 2009-11-06 |
| NCT04270604 — Biological Sample Collection for Research and Biobanking | n/a | Terminated | 1,279 | New York Stem Cell Foundation Research Institute | 2012-02-06 |
| NCT05253521 — The Role of South Asian vs European Origins on Circulating Regenerative Cell Exhaustion | n/a | Completed | 120 | Canadian Medical and Surgical Knowledge Translation Research | 2022-01-08 |
| NCT01350219 — Stem Cell Educator Therapy in Type 1 Diabetes | Phase 2 | Unknown | 100 | Throne Biotechnologies Inc. | 2010-09 |
| NCT03562208 — Autologous Bone Marrow Transplant in Chronic Insulin Dependent Diabetic Patients | Phase 2, Phase 3 | Unknown | 100 | Global Cell Med | 2018-01-01 |
| NCT03390231 — Stem Cell Educator Therapy in Diabetes | Phase 2 | Unknown | 100 | Throne Biotechnologies Inc. | 2017-11-27 |
Most recently registered
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT06938334 — A First-in-human Clinical Trial Using a Gene Therapy With Patient's Own Stem Cells to Treat Early Type 1 Diabetes | n/a | Not Yet Recruiting | n/a | Altheia Science | 2025-08-15 |
| NCT06951074 — Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes | n/a | Recruiting | n/a | Ain Shams University | 2025-04-01 |
| NCT06407297 — UCMSCs Combined With Standard Therapy for the Treatment of Newly Diagnosed Type 1 Diabetes | n/a | Unknown | n/a | Shanghai Changzheng Hospital | 2024-05-23 |
| NCT05791201 — A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes | n/a | Active Not Recruiting | n/a | Vertex Pharmaceuticals Incorporated | 2023-05-16 |
| NCT04011020 — Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes | n/a | Unknown | n/a | Throne Biotechnologies Inc. | 2022-09-20 |
Reading this honestly
A registry is a plan repository. Counting entries tells you what people intended to study, which is a weaker thing than what they found. For Diabetes (Type 1 & 2) specifically, the practical question is which registered study — if any — matches the product a provider is offering, and what its outcome measures actually are.
Frequently asked
How many stem-cell trials exist for Diabetes (Type 1 & 2)?
65 registered records mention a stem-cell intervention for this condition (2026-08-29 snapshot), of which 4 were recruiting.
Which therapy class is furthest along for Diabetes (Type 1 & 2)?
Ranked by Phase 3/4 records: MSC (3), HSCT (1), exosomes (1), PRP (0).
Does a recruiting trial mean I can be treated?
No. Trials have eligibility criteria, and joining one is not the same as buying a treatment. Paying a clinic for an unproven intervention outside a registered study gives you neither the protections nor the data collection of a trial.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
Download the query data
Query totals are full API matches; status, phase and country counts describe the first up to 400 returned records per query. Query classes overlap and must not be summed as unique trials. Counts are not treatment outcomes. Snapshot: 2026-08-29. Methods and field definitions.