What research stage is stem-cell therapy for Arterial Hypertension at?
The ladder for this condition: 5 Phase 3 or 4 records out of 35 registrations in total, snapshot 2026-08-29.
Phase distribution
| Phase label | Records | Share |
|---|---|---|
| Not applicable | 19 | 48% |
| Phase 1 | 10 | 25% |
| Phase 2 | 6 | 15% |
| Phase 4 | 3 | 8% |
| Phase 3 | 2 | 5% |
What the phase mix means for Arterial Hypertension
Registered work is early and small. That matters more here than elsewhere, because blood pressure falls in almost any trial through measurement effects, medication adherence and regression to the mean — so an uncontrolled Phase 1 showing a drop tells you close to nothing.
The later-phase studies themselves
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT07613099 — Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging | Phase 3 | Recruiting | 210 | National Heart, Lung, and Blood Institute (NHLBI) | 2026-09-02 |
| NCT01155128 — Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease | Phase 4 | Unknown | 200 | Federal University of Pelotas | 2011-09 |
| NCT06498440 — Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT | Phase 4 | Unknown | 126 | St. Joseph's Healthcare Hamilton | 2024-09-01 |
| NCT01041287 — Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells | Phase 4 | Completed | 96 | Emory University | 2009-12 |
| NCT01560845 — ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis | Phase 2, Phase 3 | Unknown | 50 | Wenzhou Medical University | 2010-06 |
How to read phase labels
Phase labels describe what a study was designed to answer. A Phase 1 result showing improvement answers a question nobody asked of it, because the design has no control arm and too few participants to distinguish an effect from noise.
Median planned enrolment across sampled studies here is 46 participants. Small single-arm studies can flag safety problems; they cannot separate a treatment effect from natural fluctuation, placebo response or regression to the mean.
The largest studies by planned enrolment
Size is a crude proxy for what a study can detect, but it separates a serious attempt from a case series presented as evidence.
| Study | Phase | Status | Planned n | Lead sponsor | Start |
|---|---|---|---|---|---|
| NCT03011541 — Stem Cell Ophthalmology Treatment Study II | n/a | Recruiting | 500 | MD Stem Cells | 2016-01 |
| NCT07157670 — Cardiovascular Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. | n/a | Not Yet Recruiting | 400 | Assistance Publique - Hôpitaux de Paris | 2025-09-15 |
| NCT01920867 — Stem Cell Ophthalmology Treatment Study | n/a | Unknown | 300 | MD Stem Cells | 2012-08 |
| NCT07613099 — Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging | Phase 3 | Recruiting | 210 | National Heart, Lung, and Blood Institute (NHLBI) | 2026-09-02 |
| NCT01155128 — Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease | Phase 4 | Unknown | 200 | Federal University of Pelotas | 2011-09 |
Frequently asked
What research stage is stem-cell therapy for Arterial Hypertension at?
5 of 35 records are labelled Phase 3 or 4 (2026-08-29).
Is a Phase 3 trial proof that it works?
No — it is a design capable of testing that question. Proof depends on the reported result, replication, and whether the outcome measured matters to patients.
Why do so many records have no phase?
Observational studies and some cell-therapy protocols are registered without a phase label. It is a registry field, not a quality rating.
Registry and literature counts retrieved 2026-08-29 (ClinicalTrials.gov API v2; PubMed E-utilities). Registration or publication volume measures research activity, not effectiveness or approval. Educational information — not medical advice; verify product, indication, legal pathway and evidence with an independent qualified physician. Page generated 2026-08-29. See our editorial standards.
More on this condition
- Arterial Hypertension: cell-therapy evidence and registered trials
- How much does stem cell therapy for Arterial Hypertension cost? (2026)
- Arterial Hypertension stem cell therapy — your questions answered (2026)
- Arterial Hypertension: cell-therapy evidence by therapy class
- MSC vs exosomes for Arterial Hypertension: what the registries show